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Abnormally large quantities of the dipeptide are produced because of the loss of feedback inhibition of -GCS by GSH

A clinical pilot study

31,32 In our study, 19% of COPD individuals reported GERD symptoms as compared with 14% in unobstructed smokers, consistent with previously cited studies showing a higher incidence of GERD in COPD patients

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Peptide therapy as a research discipline has expanded substantially over the past two decades as analytical tools for studying these cellular mechanisms have become more refined

Accordingly, both APR and GCL in the primary metabolic pathway are activated upon oxidation whereas the activity of enzymes that are part of the secondary pathway, APK and SAL1, is attenuated